Iron and Insulin Resistance in Overweight and Obese Humans

Completed · Not applicable

Conditions studied: Glucose Intolerance, Insulin Resistance, Iron Metabolism

In brief

Determine the effects of reducing whole-body iron stores in overweight/obese subjects (via one-time blood donation) on adipose tissue iron content, factors regulating iron homeostasis and lipolytic rate in adipose tissue, as well as measures of adipose tissue and whole-body insulin resistance. After a screening visit to determine eligibility, subjects will undergo a battery of tests for the determination of primary outcome measures at baseline. They will then donate 1 unit (\~500 mL) of blood (at a local blood donation center) and return for a follow-up testing 4 weeks after blood donation. During the 4-week period between study trials, subjects will be required to maintain a stable body mass and not alter their dietary or physical activity habits.

Key facts

Study ID
NCT03348020
Run by
University of Michigan
People needed
32
Starts
2018-09-01
Expected to finish
2020-02-28
Last updated by the study team
2022-03-21

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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