Verapamil for Neuroprotection in Stroke
Recruiting now · Phase 1/Phase 2
Conditions studied: Ischemic Stroke
In brief
The purpose of this research study is to test an experimental procedure called intra-arterial delivery of verapamil in patients diagnosed with acute ischemic stroke. This study investigates the safety of intra-arterial delivery of verapamil, a drug used to treat vasospasm (spasm of a blood vessel), and how it affects recovery from stroke. Recruitment is limited to patients that have received mechanical thrombectomy as standard of care.
Key facts
- Study ID
- NCT03347786
- Run by
- Global Neurosciences Institute
- People needed
- 60
- Starts
- 2017-04-20
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-01-17
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Written informed consent
- 18 years of age and over
- Acute onset focal neurologic deficit consistent with acute ischemic stroke, or computed tomographic scan consistent with acute cerebral ischemia
- Candidate for mechanical thrombectomy procedure
- Onset of symptoms less than 8 hours
- Measurable neurologic deficit (NIHSS ≥4)
- Willingness to follow up with rehabilitation therapy
- Anticipated life expectancy of at least 3 months
You may not qualify if…
- Pregnancy or suspected pregnancy (pregnancy test will be done on women of child-bearing potential)
- Hepatic and/or renal insufficiency (LFT's>3× upper limit of normal; CrCl < 30ml/min)
- Thrombocytopenia (platelet count <75,000/mm3)
- History of intolerance to verapamil
- Previous functional disability (modified Rankin > 1)
- Severe stroke (NIHSS>22)
- Stuporous or comatose
- Unlikely to be available for 90 day follow-up
Where it is running
- AtlantiCare Regional Medical Center — Atlantic City, New Jersey, United States (enrolling)
- St Mary Medical Center — Langhorne, Pennsylvania, United States
- Crozer Chester Medical Center — Upland, Pennsylvania, United States
Full record on ClinicalTrials.gov
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