Assessing Neurocognition After Cerebrovascular Intervention
Recruiting now · Not applicable
Conditions studied: Carotid Artery Diseases, Neurocognitive Dysfunction
In brief
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.
Key facts
- Study ID
- NCT03344276
- Run by
- University of California, San Diego
- People needed
- 20
- Starts
- 2021-07-15
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2025-02-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- patients >18 years of age
- ultrasound evidence of carotid stenosis; in which the patient has either 50% or greater symptomatic carotid stenosis or 70% or greater asymptomatic carotid stenosis.
You may not qualify if…
- patients <18 years of age
- patients with without compatibility for MRI
- patients requiring carotid stenting for reasons not related to long-standing stenosis
- patients requiring emergency carotid stenting for acute symptoms such as crescendo transient ischemic attacks, intolerance of physiologic blood pressure.
- Patients that do not have appropriate capacity (i.e. understand the risks and benefits associated with this study) or are unable to consent for themselves will not be included in this study.
Where it is running
- UCSD Medical Center — San Diego, California, United States (enrolling)
Full record on ClinicalTrials.gov
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