IAI for Persistent DME After Treatment With Bevacizumab And Ranibizumab

Completed · Phase 4

Conditions studied: Diabetic Macular Edema

In brief

This is a phase 4 prospective, nonrandomized, open label, interventional clinical trial. Study eyes will receive 5 required initial monthly Intravitreal Aflibercept (IAI) doses of 2 mg followed by 2q8 IAI for a total of 52 weeks; only one study eye from each patient will be enrolled.

Key facts

Study ID

NCT03340610

Run by

Southeast Retina Center, Georgia

People needed

30

Starts

2015-06-01

Expected to finish

2018-12-12

Last updated by the study team

2019-05-24

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• A patient must meet the following criteria to be eligible for inclusion in the study:
• Adults with Diabetes Mellitus 2. Documented history of ROTATE study completion (within 3 months +/- 1 week of exit visit) 3. BCVA ETDRS visual acuity letter score 20/25-20/400 4. Thickening due to DME involving the center of the macula evident on clinical exam 5. DME on OCT at baseline (>305 microns if male or >290 microns if female) as assessed on Heidelberg Spectralis SD OCT 6. At least 30 days but less than 45 days since prior 0.3 mg ranibizumab injection 7. Willing and able to comply with clinic visits and study-related procedures 8. Provide signed HIPAA statement and informed consent prior to any study procedures

You may not qualify if…

• A patient who meets any of the following criteria will be excluded from the study:
• Macular edema considered to be due to a cause other than DME (ERM, Vein Occlusion, Postop CME, uveitis)
• History of PRP within 3 months prior to enrollment or anticipated need for PRP
• History of idiopathic or autoimmune uveitis in the study eye
• Cataract surgery in the study eye within 90 days of baseline
• Any intraocular surgery within 90 days of baseline
• Vitreomacular traction or epiretinal membrane in the study eye that is thought to affect vision
• Clinically significant pre-retinal fibrosis involving the macula in the study eye per investigator judgment
• Intraocular inflammation of trace or above in the study eye
• Evidence of active infection in either eye
• Uncontrolled glaucoma in the study eye defined as a pressure of > 25 on maximal medical therapy.
• Concurrent disease in the study eye, other than DME, that could compromise VA, require medical or surgical intervention during the study or could confound interpretation of the results
• Ocular media of insufficient quality to obtain fundus and OCT images
• Current treatment for a serious systemic infection
• Administration of systemic anti-angiogenic agents within 180 days of screen
• History of yag capsulotomy within 1 month prior to enrollment
• Receipt of any treatment for DME, other than ranibizumab 0.3 mg, in the study eye at any time in the past 3 months following ROTATE study exit, (such as focal/grid macular photocoagulation, intravitreal or peribulbar corticosteroids or other anti-VEGF agents such as Macugen, 2 mg IAI,, 0.5 mg ranibizumab, or intravitreal bevacizumab)
• Any women who are pregnant, breast-feeding, or attempting to become pregnant
• Sexually active men* or women of childbearing potential** who are unwilling to practice adequate contraception during the study (adequate contraceptive measures include stable use of oral contraceptives or other prescription pharmaceutical contraceptives for 2 or more menstrual cycles prior to screening; intrauterine device [IUD]; bilateral tubal ligation; vasectomy; condom plus contraceptive sponge, foam, or jelly, or diaphragm plus contraceptive sponge, foam, or jelly)
• Contraception is not required for men with documented vasectomy. **Postmenopausal women must be amenorrheic for at least 12 months in order not to be considered of child bearing potential. Pregnancy testing and contraception are not required for women with documented hysterectomy or tubal ligation.

Where it is running

• Southeast Retina Center — Augusta, Georgia, United States

Full record on ClinicalTrials.gov

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