Oxygen Transport in Normobaric vs. Hypobaric Hypoxia
Completed · Not applicable
Conditions studied: Hypoxia, Altitude, Exercise
In brief
1\) Oxygen Transport in Normobaric versus Hypobaric Hypoxia. 2) The purpose of this study is to examine acute responses in arterial and muscle tissue oxygenation during incremental exercise in normobaric versus hypobaric hypoxia. 3) The participants in this study will consist of 12 recreationally active males and females between the ages of 19 and 45.Recreationally active is defined as participating in moderate to vigorous physical activity for 30 minutes at least 3 days per week.4) Subjects will complete an incremental cycle test to volitional fatigue in three conditions in a randomized counter-balanced order, normobaric normoxia (20.9% O2, 730 mmHg), normobaric hypoxia (14.3% O2, 730 mmHg) and hypobaric hypoxia (20.9% O2, 530mmHg). Two of the three trials will be conducted in an environmental chamber to simulate normobaric normoxia at 350 m (elevation of Omaha, NE) and normobaric hypoxia at 3094 m (elevation of Leadville, CO). The hypobaric hypoxia trial will be conducted in Leadville, Colorado at 3094 m. Trials will be separated by at least two days. Rating of perceived exertion, heart rate, blood oxygenation, respiration rate, muscle tissue oxygenation, and whole body gases will be analyzed during the trials. 5) There is no follow-up as a part of this study.
Key facts
- Study ID
- NCT03335917
- Run by
- University of Nebraska
- People needed
- 12
- Starts
- 2017-08-15
- Expected to finish
- 2018-06-01
- Last updated by the study team
- 2023-09-29
Who can join
Age: 19 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants must be recreationally active Recreationally active is defined as participating in moderate to vigorous physical activity for 30 minutes at least 3 days per week.-females or males between the ages of 19 and 45.
- All participants must be considered "low risk" according to ACSM risk stratification.
- participants must be free from any ECG or blood pressure abnormalities as assessed during maximal testing.
You may not qualify if…
- All subjects who are considered higher than "low risk" according to the ACSM risk stratification guidelines will be excluded from this study.
- Any participant under 19 years of age or over the age 45 and who list any health related condition that may interfere or become exacerbated by participating in this research would be excluded from this study.
- Participants taking any prescription drugs, other than female contraceptives, will be excluded from participation.
Where it is running
- University of Nebraska at Omaha — Omaha, Nebraska, United States
Full record on ClinicalTrials.gov
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