Study to Explore the Mechanism of Acquired Immune Escape In Participants With Metastatic Cancer Progressing on CPI Therapy

Completed · Phase 4

Conditions studied: Neoplasms

In brief

The purpose of this study is to identify mechanisms associated with acquired immune escape by comparing baseline and at-progression tissue samples from participants who derive clinical benefit from CPI treatment of metastatic cancer or hematologic malignancies.

Key facts

Study ID

NCT03333655

Run by

Hoffmann-La Roche

People needed

15

Starts

2018-02-16

Expected to finish

2022-08-04

Last updated by the study team

2022-08-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Response assessment of complete response (CR), partial response (PR), or long-term stable disease (SD) for >6 months with a cancer immunotherapy treatment for metastatic cancer or hematologic malignancies either through a marketed CPI or through participation in a Roche/Genentech CPI clinical trial.
• Availability of tissue sample.

You may not qualify if…

• Pregnant, lactating, or intending to become pregnant during the study.
• Participants receiving CPI treatment as part of a non-Roche/Genentech clinical trial.

Where it is running

• UCSF Comp Canc Ctr — San Francisco, California, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Washington University School of Medicine; Dept of Medicine/Div of Medical Oncology — St Louis, Missouri, United States
• Herbert Irving Comprehensive Cancer Center; Herbert Irving Pavillion — New York, New York, United States
• Sarah Cannon Cancer Center — Arrington, Tennessee, United States
• Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O) — Toulouse, France
• Seoul National University Hospital; Department of Oncology — Seoul, South Korea
• Asan Medical Center, Uni Ulsan Collegemedicine; Dept.Internal Medicine / Divisionhematology/Oncology — Seoul, South Korea
• Clinica Universitaria de Navarra; Servicio de oncología — Pamplona, Navarre, Spain
• Hospital Univ Vall d'Hebron; Servicio de Oncologia — Barcelona, Spain
• Barts Hospital; Institute of Cancer — London, United Kingdom

Full record on ClinicalTrials.gov

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