Closed Eye Neutrophils in Dry Eye Disease

Completed · Not applicable

Conditions studied: Dry Eye, Ocular Inflammation

In brief

The purpose of this prospective study is to evaluate different inflammatory cells that accumulate on the ocular surface, during sleep, and how these cells may contribute to dry eye disease. This study will involve at-home self-collection of tears using an eye wash method with sterile saline solution. While a diagnostic technique, the eye wash may also have a therapeutic benefit in dry eye sufferers, which will be assessed in the second phase of this project.

Key facts

Study ID

NCT03332342

Run by

University of Alabama at Birmingham

People needed

153

Starts

2017-11-08

Expected to finish

2019-05-14

Last updated by the study team

2019-05-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• able to understand and sign an informed consent and HIPAA privacy document
• greater than 18 years of age at time of informed consent
• able and willing to follow protocol instructions, including performing at-home washes of the ocular surface and subsequent delivery of those samples to campus on a regular basis
• must be willing to have blood drawn

You may not qualify if…

• contact lens wear within past three months
• current consumption of cigarettes or tobacco, including e-cigarettes
• participation in any investigational drug studies within 30 days of informed consent
• pregnancy, by self-report
• active ocular infection or inflammation
• any refractive surgery within the past year
• any present Accutane (Isotretinoin) use
• any medication usage that, in the investigator's opinion, could be expected to interfere with the study, such as current use of topical steroids, Restasis, or Xiidra
• have any uncontrolled systemic disease, that in the investigator's opinion could be expected to interfere with the study, for example, conditions associated with dry eye disease

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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