A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies
Completed · Phase 1
Conditions studied: Melanoma, Non-small Cell Lung Cancer, Breast Cancer, Gastric Cancer, Renal Cell Carcinoma, Ovarian Cancer, Cholangiocarcinoma, Bladder Urothelial Carcinoma, Pancreatic Adenocarcinoma, Colorectal Cancer, Esophageal Cancer, Hepatic Cancer, Head and Neck Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer, Other Solid Tumors, Diffuse Large B-cell Lymphoma (DLBCL), Mantle Cell Lymphoma, Indolent B-cell Lymphomas, Non-Hodgkin Lymphoma, Follicular Lymphoma, Lymphoplasmacytic Lymphoma, Waldenstrom's Disease, Marginal Zone Lymphoma, Mucosa Associated Lymphoid Tissue, Small Lymphocytic Leukemia
In brief
This is a study to determine the maximum tolerated dose (MTD) for CDX-1140 (CD40 antibody), either alone or in combination with CDX-301 (FLT3L), pembrolizumab, or chemotherapy and to further evaluate its tolerability and efficacy in expansion cohorts once the MTD is determined.
Key facts
- Study ID
- NCT03329950
- Run by
- Celldex Therapeutics
- People needed
- 132
- Starts
- 2017-12-01
- Expected to finish
- 2022-09-13
- Last updated by the study team
- 2024-03-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- HonorHealth Research Insititute — Scottsdale, Arizona, United States
- Northside Hospital, Inc. — Atlanta, Georgia, United States
- Georgia Cancer Center at Augusta University — Augusta, Georgia, United States
- Oncology Hematology West, PC dba Nebraska Cancer Specialists — Omaha, Nebraska, United States
- Icahn School of Medicine at Mount Sinai — New York, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Gabrail Cancer Center Research LLC — Canton, Ohio, United States
- Providence Portland Medical Center — Portland, Oregon, United States
- Abramson Cancer Center at the University of Pennsylvania — Philadelphia, Pennsylvania, United States
- Rhode Island Hospital (RIH) The Miriam Hospital (TMH) — Providence, Rhode Island, United States
- Houston Methodist — Houston, Texas, United States
Full record on ClinicalTrials.gov
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