Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion
Withdrawn before enrolling · Phase 3
Conditions studied: Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis, Myelopathy, Radiculopathy, Myeloradiculopathy
In brief
Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit. This occurs with traversal of the psoas muscle or direct injury to lumbosacral plexus or sympathetic ganglion. While often temporary, it can cause hip flexor weakness, thigh numbness, or pain. Several studies have demonstrated reduced patient reported pain scores following steroid administration, particularly in the early postoperative period. However, few studies have investigated the efficacy of intraoperative local injection of corticosteroid in reducing the incidence and duration of postoperative pain or neurologic injury for XLIF patients.
Key facts
- Study ID
- NCT03327272
- Run by
- Rush University Medical Center
- People needed
- 0
- Starts
- 2018-05-22
- Expected to finish
- 2020-07-24
- Last updated by the study team
- 2020-11-20
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients undergoing a 1- to 2-level XLIF
- Diagnosis: myelopathy, radiculopathy, myeloradiculopathy, stenosis, herniated nucleus pulposus, degenerative disc disease, spondylosis, osteophytic complexes, and foraminal stenosis
- Patients able to provide informed consent
You may not qualify if…
- Allergies or other contraindications to medicines in the protocol including:
- Existing history of gastrointestinal bleeding
- Lumbar spine trauma
- Unable to speak, read, or understand English
Where it is running
- Rush University Medical Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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