Autonomic Modulation in Takotsubo Syndrome

Running, not enrolling · Not applicable

Conditions studied: Takotsubo Syndrome

In brief

This is a minimal risk case-controlled single arm intervention study, including 10 patients with a prior history of takotsubo and 10-age and sex matched healthy controls. Subjects will undergo in laboratory testing to measure autonomic function. They will then undergo a 15-week program of device-guided breathing with remote measures of autonomic function obtained at home. Analysis will determine the reproducibility of home autonomic measures and the provide preliminary data to determine the efficacy of device-guided breathing on autonomic measures and quality of life in patients with takotsubo.

Key facts

Study ID

NCT03324529

Run by

NYU Langone Health

People needed

24

Starts

2021-10-01

Expected to finish

2027-06-01

Last updated by the study team

2026-03-05

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed history of takotsubo syndrome
• Healthy person with no significant past history of cardiovascular or neurological disease such as heart failure or heart attack; people with cardiovascular risk factors such as hypertension will be permitted to participate

You may not qualify if…

• Pacemaker or defibrillator implanted
• Evidence of autonomic neuropathy, alcohol or drug abuse or exposure to neurotoxins (chemotherapy).
• Diabetes

Where it is running

• New York University School of Medicine — New York, New York, United States

Full record on ClinicalTrials.gov

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