Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study

Completed · Phase 4

Conditions studied: Glaucoma; Drugs, Normal Tension Glaucoma, Primary Open-angle Glaucoma

In brief

This study evaluates the possible acute changes in peripapillary blood flow after instillation of antiglaucoma medications in patients with primary open angle glaucoma (POAG), normal tension glaucoma (NTG), or ocular hypertension (OHTN) using Optical Coherence Tomography (OCT) angiography.

Key facts

Study ID

NCT03323164

Run by

Wills Eye

People needed

35

Starts

2017-07-10

Expected to finish

2020-05-30

Last updated by the study team

2020-12-31

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of ocular hypertension, primary open angle glaucoma, or normal tension glaucoma in the study eye(s)
• Age 18-90
• Best corrected visual acuity of 20/60 or better

You may not qualify if…

• Current use of either brimonidine or timolol
• Other disease, ophthalmic or systemic, that is likely to significantly affect the OCT test in the study eye(s) including:
• More than moderate grade cataract that significantly reducing OCTA scan signal level
• Macular degeneration other than mild drusen or pigmentary changes
• Diabetic retinopathy other than mild background non proliferative retinopathy
• Prior or current macular edema
• Prior laser treatment to the retina
• Prior retinal detachment
• Prior central serous retinopathy
• Prior retinal vein or artery occlusion
• Prior inflammatory retinopathy or choroidopathy
• Keratoconus or other corneal ectasia
• Corneal scarring in central 4 mm
• Prior penetrating keratoplasty
• Ischemic optic neuropathy
• Dementia beyond early/mild memory loss
• History of cerebrovascular accident
• History of severe carotid stenosis
• History of previous ocular surgery other than non-complicated cataract extraction

Where it is running

• Glaucoma Research Center - Wills Eye Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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