Long-Term Safety Study of Tafenoquine
Completed · Phase 2 · Has a placebo group
Conditions studied: Healthy Volunteers
In brief
This randomized, double-blind, placebo controlled study will involve 600 healthy (Glucose-6-Phosphate Dehydrogenase \[G6PD\] normal) volunteers. Participants who meet the eligibility criteria will be randomized (ratio 1:1) to receive a loading dose of either tafenoquine 200 mg (2 x 100 mg tablets) or placebo daily for three consecutive days, followed by study treatment (tafenoquine 200 mg or placebo) once per week for 51 weeks, with safety follow-up visits at Weeks 4, 12, 24, and 52. All participants will return to the clinic at Week 64 for an end of study visit. If the participant has an ongoing AE at the Week 64 visit will continue to be assessed for up to 3 more times at approximately 12-week intervals or until resolution or stabilization of the AE whichever is earlier.
Key facts
- Study ID
- NCT03320174
- Run by
- 60 Degrees Pharmaceuticals LLC
- People needed
- 600
- Starts
- 2017-10-05
- Expected to finish
- 2021-07-13
- Last updated by the study team
- 2026-04-17
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
Where it is running
- Retina Consultants of Southern Colorado — Colorado Springs, Colorado, United States
- Valley Retina Institute — McAllen, Texas, United States
- Linear Clinical Research — Nedlands, Western Australia, Australia
Full record on ClinicalTrials.gov
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