Serum, Dietary and Supplemental Vitamin D's Association With Cognitive Decline
Completed
Conditions studied: Cognitive Decline, Cognitive Impairment
In brief
Serum 25(OH)D, dietary and supplemental vitamin D were shown to influence cognitive outcomes in large epidemiological studies. Sex/age-specific and race-specific associations of vitamin D status and intake were examined with longitudinal change in various cognitive domains in a large sample of ethnically and socio-economically diverse US urban adults. Two prospective waves of data from Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study were used, specifically visit 1: 2004-2009 and visit 2: 2009-2013, mean follow-up time±SD: 4.64±0.93y. Cognitive performance was assessed using 11 test scores covering domains of global cognition, attention, learning/memory, executive function, visuo-spatial/visuo-construction ability, psychomotor speed and language/verbal. Serum 25(OH)D, vitamin D intake and use of supplements containing vitamin D were the key exposures. Multiple mixed-effects linear regression models were conducted, (N=1,231-1,803, k=1.5-2.0 observation/participant).
Key facts
- Study ID
- NCT03320109
- Run by
- National Institute on Aging (NIA)
- People needed
- 3720
- Starts
- 2004-08-18
- Expected to finish
- 2013-07-07
- Last updated by the study team
- 2017-10-25
Who can join
Age: 30 and older, up to 64. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- HANDLS initially recruited 3,720 participants (Phase I, visit 1). Given that only Phase II had in-depth data including biochemical indices and cognitive performance measures, 25(OH)D was available for 1,981 participants at baseline. The corresponding sample size for dietary and supplemental vitamin D were N=2,177 and N=2,159, respectively. Complete and reliable cognitive tests at each visit varied in sample size as well. Further, the final analytic sample was determined based on exposure and covariate non-missingness at baseline and outcome non-missingness at either visit. The final analytic sizes ranged between N=1,231 and N=1,803 with k=1.5-1.9 observation/participant.
You may not qualify if…
- HANDLS participants with missing data on cognitive test score on both visits and/or missing data on exposure and covariates included in the mixed-effects regression models.
Where it is running
- Biomedical Research Center, NIA/NIH/IRP — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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