Efficacy and Safety of Fenugreek Extract on Markers of Muscle Damage and Inflammation in Untrained Males

Completed · Not applicable · Has a placebo group

Conditions studied: Muscle Damage, Inflammation

In brief

This is a randomized, repeated measures and double blind study which measures the effect of fenugreek extract on markers of muscle damage and inflammation in non-resistance trained males. Participants will complete baseline testing and then be randomized into groups. Participants will complete a 2 week, split-body resistance training program. They will then return for testing in which they will complete an overreaching protocol for 5 consecutive days. Measurements will be recorded 24 hrs after the fifth day. Participants will resume the training program for one additional week and return for final measurements.

Key facts

Study ID

NCT03318731

Run by

University of Mary Hardin-Baylor

People needed

60

Starts

2017-09-21

Expected to finish

2019-08-30

Last updated by the study team

2019-09-25

Who can join

Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Subjects will be males between the age of 18-45;
• Subjects will have not been participating in a structured resistance training program in the past 6 months;
• Subjects will be provided written and dated informed consent to participate in the study;
• Subjects will be willing and able to comply with the protocol;
• Subjects will be apparently healthy and free from disease, as determined by a health history questionnaire;
• Subjects will agree to abstain from exercise 48 hours prior to each testing visit;
• Subjects will agree to fast for 10 hours prior to each testing visit;
• Subjects will be agree to refrain from tobacco use, alcohol and/or caffeine consumption and/or smoking 12 hours prior to each testing visit;
• Subjects will agree to refrain from taking any supplement that may interfere with study supplementation for the remainder of the study.

You may not qualify if…

• Subject has taken ergogenic levels of nutritional supplements that may affect muscle mass (e.g., creatine, HMB) or anabolic/catabolic hormone levels (e.g., androstenedione, DHEA, etc.) within 3 months prior to the start of the study;
• Subject is unable to complete blood draws needed at each testing session;
• Subject reports any unusual adverse events associated with this study that in consultation with the supervising physician recommends removal from the study;
• Subject does not complete 90% of resistance training program assigned;
• Subject is unable to complete overreaching protocol during overreaching week;

Where it is running

• UMHB Human Performance Lab — Belton, Texas, United States

Full record on ClinicalTrials.gov

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