Assessment of Markers of Stress in Acute Ischemic Stroke With Hyperglycemia
Completed
Conditions studied: Ischemic Stroke, Hyperglycemia
In brief
Hyperglycemia is present in 50 percent of patients with acute ischemic stroke. Patients with hyperglycemia have higher in hospital, 30 and 90 day mortality and morbidity. Sixty percent of these patients have some form of diabetic syndrome, known or unknown. Remaining 40% of patients are not diabetic. Contrary to logic patients with non diabetic hyperglycemia (NDH) have statistically higher morbidity and mortality compared to the diabetic hyperglycemia (DH) cohort. So far multiple treatment trials (THIS, GRASP, GIST-UK, SHINE ongoing) with differing treatment goals have shown no clear benefit, however no obvious distinction was made along the diabetic and non-diabetic hyperglycemic groups. If hyperglycemia in the acute phase was the only culprit in worsening the injury, then there should be no difference in the outcomes for DH and NDH. Existing data implies that the two categories are two distinct physiological entities that are thus not amenable to same treatment. Stating it simply NDH is not an insulin deficient state where as DH is. Alternative possibility is that body and Neurons are accustomed to high sugars in diabetics and thus can tolerate higher sugars better during ischemic stroke compared to non diabetics. The overarching hypothesis is that reducing blood sugars in NDH increases stroke volume and thus consequently worsens outcome.
Key facts
- Study ID
- NCT03318679
- Run by
- University of Minnesota
- People needed
- 88
- Starts
- 2017-11-01
- Expected to finish
- 2020-12-25
- Last updated by the study team
- 2021-03-23
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with acute Ischemic stroke that present to UMMC ER.
- Age 18-100.
- Subjects are hyperglycemic (defined as blood sugar above 130mg/dl).
You may not qualify if…
- Blood sugars less than 130mg/dl.
- Age less than 18 or more than 100.
- Difficult blood draw.
Where it is running
- University of Minnesota — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.