Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)

Completed

Conditions studied: Renal Transplant, Renin-Angiotensin System, Rejection Acute Renal, Rejection Chronic Renal, Rejection of Renal Transplant

In brief

In pediatric kidney transplant patients, rejection, medication toxicity and ischemia cause early and chronic renal allograft injury, which reduces graft lifespan and patient survival. Early detection of injury would facilitate prevention and treatment. The gold standard surveillance biopsy has limitations including delayed discovery of injury. No noninvasive test identifies graft injury before it is clinically apparent. This project's goal is to develop a novel early marker of subclinical graft injury to facilitate prompt recognition and treatment.

Key facts

Study ID

NCT03317925

Run by

Wake Forest University Health Sciences

People needed

29

Starts

2014-07-16

Expected to finish

2017-04-26

Last updated by the study team

2017-11-08

Who can join

Age: 1 and older, up to 20. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 1 - 20 years
• Actively listed on the transplant list at Lucile Packard Children's Hospital at Stanford and received a renal transplant during the study enrollment period

You may not qualify if…

• Transplanted at a center other than Lucile Packard Children's Hospital at Stanford

Where it is running

• Wake Forest University Baptist Medical Center — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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