Nucleophilic Defense Against PM Toxicity (NEAT Trial)

Completed · Not applicable · Has a placebo group

Conditions studied: Air Pollution Toxicity

In brief

Carnosine is a naturally occurring peptide found in high levels in skeletal muscle and the brain and is also available commercially as a dietary supplement. Since carnosine has anti-oxidant properties and air pollution exposure induces a state of oxidative stress, the purpose of this study is to see if those taking carnosine as a dietary supplement are protected from air pollution-induced oxidative stress and adverse cardiovascular outcomes.

Key facts

Study ID

NCT03314987

Run by

University of Louisville

People needed

299

Starts

2018-04-01

Expected to finish

2022-11-01

Last updated by the study team

2026-01-06

Who can join

Age: 22 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Individuals between 22-65 years of age of either gender and all ethnicities,
• All genders and all ethnicities
• Residing in or near the Louisville metropolitan area
• Consumes some type of meat/fish at least once a month during the past 3 months
• Carnosine levels below the median level of the population
• Agrees to complete all study visits and follow study intervention regimen
• Will be living in the study area throughout the study period, with no more than 1 week away from the study area.

You may not qualify if…

• Consumed any dietary supplement more than 3 times per week in the past 4 weeks (one month)
• Current / ongoing treatment for substance abuse
• Currently undergoing treatment or have conditions which may cause participant to be immunosuppressed
• Diseases Affecting Peripheral Cell Count (i.e. Autoimmune Diseases - Hashimoto, Rheumatoid Arthritis, SLE, Rheumatoid Arthritis, Sjogren syndrome, Ankylosing Spondylitis, Takayasu arteritis, Kawasaki disease, Polyarteritis nodosa.)
• Diseases Affecting Bone Marrow capacity
• Diagnosis of any active cancer
• Recent organ / kidney transplant or replacement (Active/Long-Term Medications)
• Type 1 Diabetes Mellitus
• Untreated thyroid disease
• Untreated anemia
• Current acute infections (Influenza, fever, etc.)
• HIV positive status
• Active/current Hepatitis HepA, HepB or HepC or in past 6 months
• Currently or planning to be Pregnant / lactating
• Prisoners / vulnerable populations
• Other medical conditions that compromise completion of study
• Unwilling to provide consent

Where it is running

• Clinical Trials Unit — Louisville, Kentucky, United States

Full record on ClinicalTrials.gov

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