The Combined Aerobic Exercise and Cognitive Training (ACT) Trial: The ACT Trial

Completed · Not applicable

Conditions studied: Mild Cognitive Impairment

In brief

This multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic fitness, Alzheimer's disease \[AD\] signature cortical thickness, and default mode network \[DMN\]) in older adults with amnestic MCI (aMCI).

Key facts

Study ID

NCT03313895

Run by

Arizona State University

People needed

146

Starts

2018-07-05

Expected to finish

2024-07-17

Last updated by the study team

2025-04-25

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A clinical diagnosis of MCI
• Community-dwelling
• Age 65 years and older
• English-speaking
• Adequate visual acuity
• Verified exercise safety by medical provider
• Stable on drugs affecting cognitive and psychological status
• Verified MRI safety
• Capacity to consent

You may not qualify if…

• Geriatric Depression Scale < 5
• Resting heart rate (HR) ≤50 due to arrhythmia or ≥100 beats/min
• Neurological (e.g., dementia, head trauma), psychiatric (e.g., bipolar, schizophrenia, or depression), or substance dependency (alcohol or chemical dependency) in the past 5 years that are the main contributor to MCI
• Contraindications to exercise, e.g. unstable angina, recent surgery
• New symptoms or diseases that have not been evaluated by a health care provider
• Current enrollment in another intervention study related to cognitive improvement (reduce confounding effects on outcomes)
• Abnormal MRI findings

Where it is running

• Arizona State University — Phoenix, Arizona, United States
• Stanford University — Stanford, California, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• University of Rochester — Rochester, New York, United States

Full record on ClinicalTrials.gov

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