Locating Biomarkers in OCD Through Behavioral Tasks

Starting soon

Conditions studied: OCD, Obsessive-Compulsive Disorder

In brief

Subjects that have a diagnosis of OCD will participate in a clinical interview and cognitive tasks, during which they will be exposed to their individual OC stressors or will be asked to make decisions related to information value and quantity while measuring neural activity and filming facial reactions. This will assist investigators to look for biomarkers of that change. This study offers a unique opportunity to develop biomarkers for key domains of OCD, and other neuropsychiatric disorders, that are grounded in brain neurocircuitry at the individual-patient level. Subjects will participate in a clinical interview (Day 1), and then tasks+EEG (Day 2). Day 1 will be 4 hours or less, and Day 2 will be 2.5 hours or less.

Key facts

Study ID

NCT03313622

Run by

Baylor College of Medicine

People needed

20

Starts

2027-03-01

Expected to finish

2028-03-01

Last updated by the study team

2026-06-30

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of OCD
• Non-pregnant if female
• Minimum score of 16 on Y-BOCS
• Ability to provide informed consent

You may not qualify if…

• Those not meeting inclusion criteria listed above
• Lifetime diagnosis of psychotic disorders such as schizophrenia
• Alcohol or substance abuse/dependence within 6 months, excluding nicotine
• Deemed at high risk of suicidal behavior or impulsivity
• Pregnant or plans to become pregnant in the next 24 months

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Brown University — Providence, Rhode Island, United States
• Baylor College of Medicine — Houston, Texas, United States

Full record on ClinicalTrials.gov

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