An Efficacy and Safety Study of Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva.
Completed · Phase 3
Conditions studied: Fibrodysplasia Ossificans Progressiva
In brief
Fibrodysplasia Ossificans Progressiva (FOP) is a rare, severely disabling disease characterized by heterotopic ossification (HO) often associated with painful, recurrent episodes of soft tissue swelling (flare-ups) that lead to ankyloses of major joints with cumulative and irreversible loss of movement and disability.
Key facts
- Study ID
- NCT03312634
- Run by
- Clementia Pharmaceuticals Inc.
- People needed
- 107
- Starts
- 2017-11-30
- Expected to finish
- 2022-09-07
- Last updated by the study team
- 2023-11-29
Who can join
Age: 4 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California San Francisco, Division of Endocrinology and Metabolism — San Francisco, California, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- University of Pennsylvania, Internal Medicine — Philadelphia, Pennsylvania, United States
- Hospital Italiano de Buenos Aires, Tte General Juan Domingo Peron 4190 — Buenos Aires, Argentina
- Royal North Shore Hospital — Saint Leonards, New South Wales, Australia
- Queensland University of Technology — Woolloongabba, Queensland, Australia
- Hospital Israelita Albert Einstein — São Paulo, São Paulo, Brazil
- Hospital for Sick Children, 555 University Avenue — Toronto, Ontario, Canada
- Toronto General Hospital — Toronto, Ontario, Canada
- Groupe Hospitalier Necker Enfants Malades — Paris, France
- Istituto Giannina Gaslini — Genoa, Liguria, Italy
- The University of Tokyo Hospital — Tokyo, Bunkyo-ku, Japan
- Hospital Universitari i Politècnic La Fe, Unidad de Reumatología Pediatrica — Valencia, Avinguda de Fernando Abril Martorell, Nº 106, Spain
- Norrlands Universitetssjukhus — Umeå, Sweden
- Royal National Orthopaedic Hospital, Brockely Hill — Stanmore, United Kingdom
Full record on ClinicalTrials.gov
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