Treatment of Supine Hypertension in Autonomic Failure (CPAP)

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Supine Hypertension, Autonomic Failure

In brief

Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. The purpose of this study is to assess whether continuous positive airway pressure (CPAP) decreases blood pressure in autonomic failure patients with supine hypertension.

Key facts

Study ID

NCT03312556

Run by

Vanderbilt University Medical Center

People needed

12

Starts

2017-09-21

Expected to finish

2026-12-21

Last updated by the study team

2025-11-06

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with autonomic failure and with supine hypertension from all races

You may not qualify if…

• All medical students
• Pregnant women
• High-risk patients (e.g. heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)
• History of serious allergies or asthma.

Where it is running

• Autonomic Dysfunction Center/ Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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