Regulating Homeostatic Plasticity and the Physiological Response to rTMS
Stopped early · Not applicable · Has a placebo group
Conditions studied: Tinnitus
In brief
This device-study includes a pilot, physiological investigation of normal human subjects. The aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry as measured by EEG recording. Currently, the application of non-invasive neuromodulation is rarely guided by detailed knowledge of how neural activity is altered in the brain circuits that are targeted for intervention. This gap in knowledge is problematic for interpreting response variability, which is common. To address this gap, the current proposal aims to combine two forms of neuromodulation sequentially, transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), to regulate homeostatic plasticity prior to rTMS delivery at different frequencies of rTMS. Homeostatic plasticity, the initial activation state of a targeted circuit, is a key determinant of whether rTMS induces long term potentiation (LTP) or long term depression (LTD) Yet, homeostatic plasticity is rarely measured or controlled in rTMS studies. We aim to control homeostatic plasticity by preconditioning the targeted circuits with tDCS prior to rTMS delivery. The protocol included an exploratory aim to examine physiological changes in patients with tinnitus but this aim was not part of the pilot physiological investigation and it could not be completed due to funding limitations.
Key facts
- Study ID
- NCT03309696
- Run by
- University of Arkansas
- People needed
- 10
- Starts
- 2017-11-16
- Expected to finish
- 2019-10-01
- Last updated by the study team
- 2020-11-17
Who can join
Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- complete the informed consent process
- men and women, age: 21-65 years
- negative pregnancy test (female subjects of childbearing age must take a pregnancy test).
You may not qualify if…
- a personal or family history of epilepsy,
- severe head injury, aneurysm, stroke, previous cranial neurosurgery,
- sever or recurrent migraine headaches,
- metal implants in the head or neck, a pacemaker,
- pregnancy,
- medications that lower seizure threshold,
Where it is running
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
Full record on ClinicalTrials.gov
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