SAHaRA: A Randomized Controlled Trial

Completed · Not applicable

Conditions studied: Subarachnoid Hemorrhage, Aneurysmal

In brief

The SAHaRA trial will clarify the role of treating anemia with Red Blood Cell (RBC) transfusion in a unique and vulnerable patient population, and determine whether that impacts on functional outcomes and mortality. It will guide best practice standards and clarify the optimal RBC transfusion strategy in patients with aSAH.

Key facts

Study ID

NCT03309579

Run by

Ottawa Hospital Research Institute

People needed

742

Starts

2018-02-12

Expected to finish

2024-08-22

Last updated by the study team

2024-11-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years old at time of SAH
• First ever episode of aneurysmal SAH
• Diagnosis of aSAH as confirmed by treating physician (eg: neurosurgeon or neuro- interventionalist) and supported by blood in subarachnoid space (e.g. cranial imaging or cerebrospinal fluid positive for xanthochromia, surgical visualization) that is the result of a ruptured aneurysm (e.g. direct visualization, cranial imaging or catheter angiogram)
• Hb ≤100g/L within 10 days following aSAH (defined by first day of hospital presentation)

You may not qualify if…

• Physician and or family decision to withdraw/withhold active medical care at time of enrolment
• Active bleeding with hemodynamic instability at time of enrolment
• Patients with contraindication or known objection to blood transfusions
• SAH due to mycotic aneurysm, infundibulum and vascular malformations.

Where it is running

• University of Colorado School of Medicine — Aurora, Colorado, United States
• Emory University School of Medicine — Atlanta, Georgia, United States
• Rush University Medical Center — Chicago, Illinois, United States
• Nepean Hospital — Kingswood, New South Wales, Australia
• Prince of Wales Hospital — Randwick, New South Wales, Australia
• Royal North Shore Hospital — St Leonards, New South Wales, Australia
• Royal Brisbane & Women's Hospital — Herston, Queensland, Australia
• The Alfred — Melbourne, Victoria, Australia
• Foothills Medical Center — Calgary, Alberta, Canada
• University of Alberta Hospital — Edmonton, Alberta, Canada
• Vancouver General Hospital — Vancouver, British Columbia, Canada
• Royal Jubilee Hospital — Victoria, British Columbia, Canada
• Winnipeg Health Sciences Center — Winnipeg, Manitoba, Canada
• Nova Scotia Health Authority — Halifax, Nova Scotia, Canada
• Hamilton Health Sciences Center — Hamilton, Ontario, Canada
• Kingston Health Sciences Centre — Kingston, Ontario, Canada
• London Health Sciences Center — London, Ontario, Canada
• Shane English — Ottawa, Ontario, Canada
• Sunnybrook Research Institute — Toronto, Ontario, Canada
• Centre hospitalier de l'Université de Montréal — Montreal, Quebec, Canada
• Montreal Neurological Institute and Hospital — Montreal, Quebec, Canada
• Centre hospitalier universitaire de Québec-Université Laval — Québec, Quebec, Canada
• Centre hospitalier universitaire de Sherbrooke — Sherbrooke, Quebec, Canada

Full record on ClinicalTrials.gov

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