HIV-1 and Brain Interaction on Smoking Comorbidity

Withdrawn before enrolling · Not applicable

Conditions studied: Smoking

In brief

People living with HIV-1 have high rates of cigarette smoking, which may be related to nicotinic interaction with HIV-1 infection and brain function levels. The proposed project aims to understand these pathways using translational brain imaging and HIV-1 reactivation studies. The study proposes a targeted nicotine-brain investigation of the nicotinic effects in HIV-1 infection from cellular to brain circuitry levels.

Key facts

Study ID

NCT03308331

Run by

University of Maryland, Baltimore

People needed

0

Starts

2019-12-01

Expected to finish

2025-10-30

Last updated by the study team

2020-03-10

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects between ages 18-60 in good health
• Ability to give written informed consent
• For people living with HIV: should be diagnosed with HIV two years or more and on ART two years or more
• For people living with HIV: should have achieved virologic suppression (defined as viral loads of ≤ 200 copies/ml), and without current signs of reactivation

You may not qualify if…

• Inability to sign informed consent
• Unable to undergo MRI scanning due to metallic devices or objects (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips or other implanted metal parts) or claustrophobic to the scanner
• Any major medical illnesses to include, but not limited to, uncontrolled high blood pressure or high blood sugar, cardiovascular disease, asthma, peripheral vascular diseases, coagulopathies, history of superficial or deep vein thrombosis as per medical history
• Current substance-induced psychiatric disorders
• Significant alcohol or other drug use, other than nicotine dependence or marijuana use
• Gross structural abnormalities and/or have a history of syncope
• Positive urine pregnancy tests
• Any neurological illnesses to include, but not limited to, seizure disorders, multiple sclerosis, movement disorders, or history of head trauma, CVA, CNS tumor,
• For people living with HIV: having AIDS or non-AIDS-defining cancer or active CNS and other opportunistic disease
• For people living with HIV: on active treatment of hepatitis C virus (HCV)

Where it is running

• University of Maryland School of Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.