Feasibility and Acceptability of Implementing a Clinic-based Physical Activity Coaching Intervention in People With Premanifest and Early Stage HD

Completed · Phase 1/Phase 2

Conditions studied: Huntington's Disease

In brief

This study will evaluate the feasibility and acceptability of a clinic-based physical activity coaching intervention in people with pre-manifest and early stage Huntington's Disease (HD). Fourteen individuals with premanifest and early stage HD will be recruited to participate in a 4 month coaching intervention. Feasibility will be assessed by recruitment and retention rates, and acceptability will be assessed by participant interviews. Participants will also be evaluate at baseline and following the coaching intervention to explore preliminary efficacy in terms of physical activity, self efficacy, disease-specific motor and cognitive function, walking endurance and strength.

Key facts

Study ID

NCT03306888

Run by

Teachers College, Columbia University

People needed

14

Starts

2017-10-10

Expected to finish

2019-04-01

Last updated by the study team

2019-05-30

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• For premanifest - Confirmatory genetic testing for Huntington disease (HD) and diagnostic confidence score of 0-3 on Unified Huntington Disease Rating Scale, indicating pre-manifest disease state. For manifest HD - Confirmatory genetic testing for HD or confirmed clinical diagnosis of HD by neurologist
• Successful completion of Physical Activity Readiness Questionnaire (PAR-Q), or medical clearance from General Practioner
• For potential participants over age 60, a minimum score of 24 on the Mini-Mental State Examination (MMSE) (completed within 3 months) will be required for capacity to consent.
• For potential participants age 60-65, successful pass of electrocardiogram screen will be required.

You may not qualify if…

• Musculoskeletal injury that would interfere with participation in an exercise program
• Currently participating in a structured exercise program 3 times per week or more
• Uncontrolled psychiatric or behavioral problems that would interfere with participation in an exercise program

Where it is running

• Columbia University — New York, New York, United States

Full record on ClinicalTrials.gov

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