Impact of Brain Connectome and Personality on Cognitive Rehabilitation in Multiple Sclerosis

Completed · Not applicable

Conditions studied: Multiple Sclerosis

In brief

This study aims to apply baseline MRI and neuropsychological measures to predict patient responses to behavioral cognitive rehabilitation. Training will take place over 12 weeks, 1 hour per day, 5 days per week. The investigator hypothesizes the following: \[1a\] The investigator expects that individuals with low baseline Conscientiousness will experience a lower magnitude of overall cognitive improvement following rehabilitation 1. b\] The investigator expects the impact of Conscientiousness on fidelity of rehabilitation will in part be moderated by individual differences in program adherence and executive function 2. a\] The investigator expects that individual differences in structural and functional connectome disturbances will in part explain differences in participant responses to cognitive rehabilitation. This study will also serve to supplement the sample of participants for the current IRB approved study ((IRB: 603069, Title: A case-control, 5-year follow-up study of cardiovascular, environmental and genetic risk factors for disease progression in patients with multiple sclerosis.

Key facts

Study ID

NCT03306875

Run by

State University of New York at Buffalo

People needed

50

Starts

2017-11-01

Expected to finish

2018-10-20

Last updated by the study team

2018-11-26

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• For all subjects:
• males and females above age 18
• fluent in English
• education >9 years
• Additional inclusion criteria for MS patients are as follows:
• Clinically definite MS diagnosis
• Expanded Disability Status Scale (EDSS) ≤ 6.5
• MS patients must be relapse-free and stable from the time of their MRI acquired for the CEG-MS study
• Willing and able to comply with the study procedures for the duration of the trial

You may not qualify if…

• history of serious medical or psychiatric illness (other than MS in the patient group) that may affect cognitive functioning
• color-blindness
• history of developmental disability
• past or current alcohol or substance dependence
• History of major depressive disorder, bipolar disorder, or psychotic disorder predating the onset of MS
• History of traumatic brain injury as defined by trauma causing loss of consciousness or transient post-traumatic or retrograde amnesia exceeding 5 min
• Other pathology related to MRI abnormalities

Where it is running

• Jacobs Comprehensive Multiple Sclerosis Treatment and Research Center — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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