Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis

Completed · Not applicable

Conditions studied: Eosinophilic Esophagitis

In brief

Presently, the only method available to monitor disease activity in Eosinophilic Esophagitis (EoE) is endoscopy with pathological review of biopsies. The overall goal of this study is to determine the ability of the Esophageal String Test (EST), a minimally invasive capsule based technology, to measure disease activity in children with EoE. Additionally, to determine esophageal distensibility in children presenting with EoE by using the EndoFLIP (functional luminal imaging probe) device during endoscopic procedures.

Key facts

Study ID

NCT03305653

Run by

University of Colorado, Denver

People needed

21

Starts

2018-05-01

Expected to finish

2019-03-01

Last updated by the study team

2021-07-06

Who can join

Age: 7 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provide signed and dated informed consent form.
• Willing to comply with all study procedures and be available for the duration of the study.
• Male or female, aged 7 to 18 years old, inclusive
• Undergoing upper Endoscopy with biopsy for clinical care at CHCO or CHOP
• Current or historical diagnosis of EoE, or suspected of having EoE

You may not qualify if…

• Known connective tissue disease, other eosinophilic disorders
• Past history of caustic injestion, esophageal surgery or other esophageal injury
• Known inflammatory bowel disease or esophageal motility disease (achalasia)
• Unwilling or unable to swallow the EST
• Oral or intravenous steroids in the preceding 60 days (not including swallowed topical fluticasone, budesonide, etc)
• Pregnancy
• Participation in a clinical study that may interfere with participation in this study

Where it is running

• Children's Hospital Colorado — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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