Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage

Completed · Phase 4

Conditions studied: Cervical Incompetence

In brief

This study aims to compare the effect of chloroprocaine vs. bupivacaine on duration of motor block and duration until meeting discharge criteria in patients undergoing cervical cerclage. The hypothesis is that chloroprocaine will result in faster resolution of motor block.

Key facts

Study ID

NCT03305575

Run by

Tufts Medical Center

People needed

10

Starts

2017-10-13

Expected to finish

2018-08-24

Last updated by the study team

2020-08-25

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• ASA classification II or III females
• Age: 18-45 years old
• BMI ≤ 50 kg/m2
• Singleton pregnancy
• Simple prophylactic cervical cerclage
• Planning neuraxial anesthesia

You may not qualify if…

• Abdominal and complex cervical cerclage (e.g. bulging bag)
• Contraindication to neuraxial anesthesia
• Known hypersensitivity to chloroprocaine (a.k.a. Ester allergy), paraaminobenzoic acid (PABA) or bupivacaine (a.k.a. Amide allergy)
• Pseudocholinesterase deficiency
• Concomitant use with ergot-type oxytocic drugs

Where it is running

• Tufts Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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