Cerebral MRI During Sleep

Completed

Conditions studied: Sleep

In brief

Recent studies in animal models have suggested a critical role for cerebrospinal fluid and Interstitial fluid flux through cerebral parenchyma for removal of byproducts of cellular metabolism and hence in maintaining the health of the brain. This effect is modulated during sleep, suggesting a potentially important mechanism for sleep to maintain both acute homeostasis and long-term cerebral health. The central goal of these studies is to develop a sensitive MRI biomarker of cerebral conformational changes during sleep. This exploratory work aims to establish the sensitivity and reproducibility of MRI as a non-invasive neuroimaging assessment of cerebral changes during natural sleep and sedation.

Key facts

Study ID

NCT03304652

Run by

University of California, San Diego

People needed

11

Starts

2017-10-01

Expected to finish

2018-10-31

Last updated by the study team

2019-03-14

Who can join

Age: 18 and older, up to 59. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Healthy Adults

You may not qualify if…

• age not in range 18-59
• smoking / recreational drug use
• pregnant women / breast feeding
• contraindication to MRI
• contraindications to Zaleplon
• history of cardiovascular pulmonary or cerebral disease (hypertension (diastolic >90 mmHg, systolic > 150 mmHg), unstable cerebrovascular syndromes, prior history of cardiac arrhythmias, unstable angina, chronic obstructive pulmonary disease).
• Current SSRI antidepressant medication
• History of sleep disorder or currently taking sedative / stimulant medication

Where it is running

• UC San Diego — San Diego, California, United States

Full record on ClinicalTrials.gov

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