Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy Subjects

Completed · Phase 1

Conditions studied: Healthy

In brief

This is a Phase 1, multiple dose, open-label pharmacokinetic study conducted in healthy adult male and female subjects to determine and compare plasma, epithelial lining fluid (ELF) and alveolar macrophage (AM) concentrations of ETX2514 and sulbactam in healthy adult subjects after intravenous infusion of ETX2514 1.0 g given concurrently with intravenous sulbactam 1.0 g, administered every 6 hours with each infused over 3 hours, for 3 consecutive doses

Key facts

Study ID

NCT03303924

Run by

Entasis Therapeutics

People needed

30

Starts

2017-08-21

Expected to finish

2017-10-26

Last updated by the study team

2017-11-09

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male or female subject, between 18 and 55 years of age (both inclusive) at the time of screening.
• Body mass index (BMI) ≥ 18.0 kg/m2 and ≤ 32.0 kg/m2 and weight between 55.0 and 100.0 kg (both inclusive).
• Be in general good health without clinically significant medical history as judged by the Principal Investigator.
• Provide voluntary written informed consent prior to any study procedures and is willing and able to comply with the prescribed treatment protocol and evaluations.
• Non-tobacco/nicotine-containing product users for a minimum of 6 months prior to screening.
• Clinical laboratory values within the normal limits as defined by the clinical laboratory, unless the Principal or sub-Investigator decides that out-of-range values are not clinically significant.
• If male, agree to be sexually abstinent or agree to use two approved methods of contraception when engaging in sexual activity from screening until 90 days following the last administration of the study drug, and to not donate sperm during same time period. In the event that the sexual partner is surgically sterile, contraception is not necessary.
• Female subjects of child bearing potential must agree to practice two highly effective methods of birth control (as determined by the Investigator; one of the methods must be a barrier technique) from Screening until 30 days after the last dose of study drug.
• Postmenopausal females (defined as 12 months spontaneous amenorrhea) with serum follicle stimulating hormone levels ≥ 40 mlU/mL or females who have undergone one of the following sterilization procedures at least 6 months prior to screening (and is documented):
• Bilateral tubal ligation
• Hysterectomy
• Hysterectomy with unilateral or bilateral oophorectomy
• Bilateral oophorectomy.

You may not qualify if…

• History of any moderate or severe hypersensitivity or allergic reaction to any β-lactam antimicrobial (e.g., penicillin, cephalosporin, sulbactam or carbapenem)
• History or presence of significant oncologic, cardiovascular, pulmonary, hepatic, renal, hematological, gastrointestinal, endocrine, immunologic, dermatologic, neurological, or psychiatric disease.
• Calculated creatinine clearance less than 60 mL/min (Cockcroft-Gault method) at screening or confinement.
• Positive alcohol breath test or urine drug screen test at screening or confinement.
• Positive testing for HIV, Hepatitis B or Hepatitis C.
• History or presence of alcohol or drug abuse within the 2 years prior to screening.
• Excessive intake of alcohol, defined as an average daily intake of greater than three units, or an average weekly intake of greater than 21 units (one unit is equivalent to 1 can or bottle (12 oz) of beer, or 1 measure (1.5 oz) of spirits, or 1 glass (5 oz) of wine) in the last 6 months prior to screening.
• History of allergic or other serious adverse reactions to lidocaine or amide anesthetic agents.
• Clinically significant pulmonary or any other disease that prevents a subject from undergoing bronchoscopy with pulmonary lavage.
• Spirometry results showing an forced expiratory volume at one second (FEV1) <80% of predicted.
• Use of probenecid within 30 days before confinement.
• Use of medication, except for acetaminophen which is allowed up to 3 days before confinement. Multivitamins and vitamin C are allowed up to 7 days before confinement (Day 1). All other medication (including over the counter medication, health supplements, and herbal remedies such as St. John's Wort extract must have been stopped at least 14 days prior to confinement), unless agreed as non-clinically relevant by the Principal Investigator.
• Engagement in strenuous activity within 96 hours of confinement (Day 1) until discharge.
• History of seizures, head injury or meningitis (e.g., epilepsy).
• History of bleeding disorders.
• History or evidence of difficulty in donating blood.
• Use of any prescription medication (with the exception of hormonal contraceptives or hormone replacement therapy for females) within 14 days prior to confinement.
• Blood donation/plasma donation or significant blood loss (i.e., >500 mL) within 60 days prior to screening.
• Participation in another investigational drug or device study or treated with an investigational drug within 30 days or five half-lives (whichever is longer) prior to screening.
• Females who are pregnant or lactating.
• Surgery within the past three months prior to screening determined by the investigator to be clinically relevant.
• Any acute illness including clinically significant infection within 30 days prior to screening.
• Subjects who have any of the following abnormalities on laboratory values at screening or prior confinement including:
• White blood cell count < 3,000/mm3, hemoglobin < 11g/dL.
• Absolute neutrophil count <1,200/mm3, platelet count <120,000/mm3.

Where it is running

• Pulmonary Associates, PA — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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