0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka

Stopped early · Phase 3

Conditions studied: Anesthesia

In brief

Total knee and hip replacements are some of the most common orthopedic procedures that require aggressive postoperative pain management. This management helps us to improve clinical outcomes such as participation in early physical therapy, hospital discharge, and patient satisfaction. Based on the recent anatomical evidence and the investigator's knowledge of the complexity of the knee joint innervation the investigator proposes a new regional anesthesia technique that provides a complete sensory blockade and better analgesia while preserving the quadriceps strength and avoiding the potential for foot drop caused by inadvertent blockade of the common peroneal nerve.

Key facts

Study ID

NCT03303794

Run by

Montefiore Medical Center

People needed

25

Starts

2017-10-25

Expected to finish

2018-06-27

Last updated by the study team

2020-03-20

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All patients undergoing unilateral total knee replacement due to OA or rheumatoid arthritis
• Ages 40- 80 years old
• American Society of Anesthesiologists class I-III

You may not qualify if…

• Refusal or absolute medical contraindication to peripheral nerve block
• refusal or absolute medical contraindication to spinal anesthesia
• conversion of spinal anesthesia to general anesthesia is obtained
• inability to cooperate
• allergy to any drug used in this study
• daily intake of opioids (tramadol, morphine, oxycodone, methadone, fentanyl)
• alcohol dependence or use of any illegal drugs within the last month
• inability to perform the mobilization test and timed up and go (TUG) test pre-operatively

Where it is running

• Montefiore Hutchinson Campus — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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