A Study to Evaluate the Safety, Tolerability and Immunogenicity of an Investigational RSV Vaccine Candidate (Ad26.RSV.preF) in Adults 18 to 50 Years of Age, and RSV-seropositive Toddlers 12 to 24 Months of Age

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Respiratory Syncytial Viruses, Respiratory Tract Infections

In brief

The purpose of this study is to assess the safety and tolerability of an intramuscular regimen of two doses (1\*10\^11 viral particles \[vp\]) of an investigational respiratory syncytial virus (RSV) vaccine candidate (adenovirus serotype 26 respiratory syncytial virus pre-fusion conformation stabilized F protein \[pre-F\] \[Ad26.RSV.preF\]) in adults aged 18 to 50 years and RSV-seropositive toddlers aged 12 to 24 months.

Key facts

Study ID: NCT03303625
Run by: Janssen Vaccines & Prevention B.V.
People needed: 48
Starts: 2017-11-29
Expected to finish: 2020-04-21
Last updated by the study team: 2025-05-25

Who can join

Age: 1 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Adults Participants:
Participant must be in good health, without significant medical illness, on the basis of physical examination, medical history, and vital signs measurement
Participant must be healthy on the basis of clinical laboratory tests performed at screening. If the results of the laboratory screening tests are outside the local laboratory normal reference ranges and additionally within the limits of toxicity Grade 1 according to the United stated (US) Food and Drug Administration (FDA) toxicity tables, the participant may be included only if the investigator judges the abnormalities or deviations from normal to be not clinically significant and appropriate and reasonable for the population under study. This determination must be recorded in the participant's source documents and initialed by the investigator
All women of childbearing potential must have a negative highly sensitive serum beta-human chorionic gonadotropin (Beta-hCG) pregnancy test at screening and a negative urine Beta-hCG pregnancy test immediately prior to each study vaccine administration
Pediatric Participants:
Participant is the product of a normal term pregnancy greater than and equal to (>=) 37 weeks, with a minimum birth weight of 2.5 kilogram (kg)
Participants must be in good health without any significant medical illness on the basis of physical examination, medical history, and vital signs performed at screening

You may not qualify if…

Adults Participants:
Participant has acute illness (this does not include minor illnesses such as diarrhea) or temperature >=38.0 ºC (degree celsius)/100.4 °F (fahrenheit) within 24 hours prior to the first dose of study vaccine
Participant has a history of an underlying clinically significant acute or chronic medical condition or physical examination findings for which, in the opinion of the investigator, participation would not be in the best interest of the participant (example, compromise the well-being) or that could prevent, limit, or confound the protocol-specified assessments
Participant has history of malignancy within 5 years before screening (exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situ of the cervix, or malignancy, which is considered cured with minimal risk of recurrence)
Pediatric Participants:
Participant's weight is below 10th percentile according to World Health Organization (WHO) pediatric growth and weight charts
Participant has any clinically significant acute or chronic medical condition that, in the opinion of the investigator, would preclude participation: example, history of seizure disorders, bleeding/clotting disorder, autoimmune disease, active malignancy, systemic infections, congenital heart disease, history of any pulmonary condition requiring medication, atopy, reactive airway disease, medically-confirmed wheezing, bronchoconstriction or treatment with a beta2 agonist, cystic fibrosis, bronchopulmonary dysplasia, chronic pulmonary disease, medically-confirmed apnea, hospitalization for respiratory illness, or mechanical ventilation for respiratory illness

Where it is running

Heartland Research Associates, LLC — Newton, Kansas, United States
Järvenpään rokotetutkimusklinikka — Jarvenpaa, Finland
University of Tampere/Vaccine Research Center — Tampere, Finland
University of Tampere/Vaccine Research Center — Turku, Finland
Royal Manchester Children's Hospital — Manchester, United Kingdom
Oxford Vaccine Group — Oxford, United Kingdom
University Hospital Southampton NHS Foundation Trust — Southampton, United Kingdom

Full record on ClinicalTrials.gov

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