Short-Term Endogenous Hydrogen Sulfide Upregulation

Completed · Not applicable

Conditions studied: Carotid Stenosis, Caloric Restriction

In brief

This research study will compare the impact of dietary restriction pre-operatively before carotid endarterectomy compared to the standard nutrition that a patient typically eats. The investigators want to find out how patients comply and generally how well patients do with this type of dietary restriction before their surgery since animal studies suggest that short - term dietary restriction may be beneficial before surgery.

Key facts

Study ID

NCT03303534

Run by

Brigham and Women's Hospital

People needed

9

Starts

2017-09-14

Expected to finish

2018-06-01

Last updated by the study team

2018-06-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• consenting adults (men and women)
• clinical indication for carotid endarterectomy (CEA) as determined by attending vascular surgeon
• if symptomatic, patients must be able to safely have surgery timed for PCR intervention

You may not qualify if…

• intolerance or allergy to any ingredients in the PCR diet (ScandiShake ingredients or almond milk/nuts)
• active infection
• pregnancy
• malnutrition determined by serum albumin lower than BWH reference value of 3.5 g/dL
• active drug dependency or alcoholism that could interfere with protocol adherence
• active non-cutaneous cancer under treatment with chemotherapeutic

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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