Oral Microbiome and Pancreatic Cancer

Completed

Conditions studied: Pancreatic Cancer

In brief

This is a prospective population based study to examine the relationship of oral and pancreatic microbiome, and their functions, to pancreatic cancer risk. The identification of specific oral bacteria and their functional relationship to pancreatic cancer will advance scientific knowledge on the etiology of pancreatic cancer. This could provide a new microbially-based research paradigm, possibly leading to new drug targets for this disease. Second, the oral bacteria may serve as a readily accessible, non-invasive biomarker for subsequent pancreatic cancer risk, which help to identify people at high risk of this disease. Finally, the identified oral bacteria may lead to microbial prophylactic preventions, with antibiotic therapy aimed at eradicating the specific species associated with increased cancer risk or, alternatively, combined with probiotics to introduce species that are associated with a decreased cancer risk. Thus, the study outcomes will lead to actionable means for pancreatic cancer prevention.

Key facts

Study ID

NCT03302637

Run by

NYU Langone Health

People needed

732

Starts

1992-12-01

Expected to finish

2010-12-01

Last updated by the study team

2017-10-06

Who can join

Age: 55 and older, up to 74. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• DNA extracted from oral wash samples from NIH-PLCO and ACS-CPS cohorts

Where it is running

• New York University School of Medicine — New York, New York, United States

Full record on ClinicalTrials.gov

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