Role of Chemokine and Chemokine Receptor in Psoriasis
Withdrawn before enrolling
Conditions studied: Psoriasis
In brief
This study aims to elucidate the role of Chemokine and chemokine receptor in the pathogenesis of Psoriasis by using human psoriasis skin xenograft SCID mouse model. The hypothesis is that chemokine and chemokine receptor play important roles in psoriasis and establishment of human skin xenograft mouse model provide excellent platform to test the hypothesis.
Key facts
- Study ID
- NCT03302390
- Run by
- University of California, Davis
- People needed
- 0
- Starts
- 2017-04-17
- Expected to finish
- 2018-04-13
- Last updated by the study team
- 2018-10-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects 18 years of age or greater
- Subjects need to fulfill the diagnostic evidence of psoriasis with or without psoriatic arthritis
- Subject may take the following medicines: NSAID, hydroxychloroquine, sulfasalazine, prednisone (<10 mg/day), Methotrexate (10 mg/week)
- Subject needs to stop topical skin preparations other than emollients in one small plaque of psoriasis for 3-4 wks from where the shave biopsy will be taken
- Willing and able to provide informed consent in English
You may not qualify if…
- Subjects less than 18 years old
- no clinical evidence of psoriatic skin
- Subjects with contraindications for biopsy, and patients receiving anticoagulants
- Subjects with active hepatitis B or Hepatitis C infection
- Subjects with concomitant inflammatory diseases such as inflammatory bowel disease, gout
- Subjects who are taking the following systemic biological therapies for psoriasis: cyclosporine, methotrexate, prednisone, acitretin, sulfasalazine, certolizumab, etanercept, adalimumab, infliximab, golimumab, secukinumab, ustekinumab, and apremilast. Other systemic medications may exclude the subject from the study.
Where it is running
- UC Davis — Sacramento, California, United States
Full record on ClinicalTrials.gov
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