Yoga for Fatigue in the Survivors of Bone Marrow Transplantation

Completed · Not applicable

Conditions studied: Fatigue, Cancer

In brief

Cancer-related fatigue (CRF) after hematopoietic cell transplantation (HCT) is a persistent problem that limits activities and causes distress. Considering the high prevalence of CRF among HCT survivors and the limitations of currently existing treatments, there is a pressing need for establishing safe and effective options for reducing CRF after HCT. Based on evidence supporting the use of yoga for CRF in non-HCT populations, yoga is one option worthy of evaluation for ameliorating CRF in HCT patients. Yoga is easy to implement, may be appealing to HCT patients, and can be self-administered, which would encourage long-term use and potentially lead to a better control of persistent CRF in HCT survivors. The primary aim of the proposed study is to assess the feasibility of a yoga intervention for HCT survivors with CRF. Outcomes from this feasibility study will provide the information needed to design a larger, adequately powered randomized controlled trial to evaluate yoga for CRF in HCT survivors. This study will employ a mixed-methods, single-arm, pretest-posttest design with focus groups. Twenty HCT survivors who report at least moderate fatigue will be recruited from the HCT clinic, Michigan Medicine. Participants will be enrolled in a six-week Restorative yoga program. The program will consist of a weekly, 60-minute yoga group class led by a certified yoga instructor along with twice-weekly home practice using yoga DVD.

Key facts

Study ID

NCT03299465

Run by

University of Michigan

People needed

20

Starts

2017-12-22

Expected to finish

2018-07-31

Last updated by the study team

2018-08-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult HCT survivors as defined by being at least 100 days post autologous or allogeneic transplantation for a malignant disease. There is no restriction to enrollment by donor type, donor cell source, presence or absence of graft versus host disease.
• Age ≥ 18 years at the time of transplant.
• A history of persistent CRF as defined by a perception of general CRF for at least one month before enrollment.
• A history of at least moderate CRF as defined by a CRF score of 4 or more on a 10-point Visual Analog Scale.
• Participants who are deemed qualified for yoga movements according to the Yoga Qualifying Movements Screening Checklist (a checklist developed by researchers at the University of California, Los Angeles to promote yoga safety through assessing the eligibility of each patient)

You may not qualify if…

• A self-reported current practice of yoga or any other mind-body therapy, including but not limited to meditation or hypnosis therapy in the past 30 days prior to study enrollment.
• Subjects currently on supplemental oxygen support.
• Subjects currently receiving hemodialysis.
• Subjects currently admitted to an inpatient unit at Michigan Medicine.
• Subjects with an uncontrolled, active infection. Subjects with viremia (Cytomegalovirus or other) may be enrolled, provided they are on active therapy and at the discretion of the treating physician.
• Subjects who have relapsed after their autologous or allogeneic transplant.

Where it is running

• Cancer Center — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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