Sedative-Anxiolytic Effects on Simulated Driving Performance

Completed · Phase 4 · Has a placebo group

Conditions studied: Psychomotor Impairment

In brief

This study evaluates the effect of anxiety drugs taken at night on the ability to drive a car the next day. Participants will receive alprazolam, placebo, or zolpidem at night before bed or in the morning before using a driving simulator to assess impairment.

Key facts

Study ID

NCT03297944

Run by

Marion Coe

People needed

15

Starts

2017-09-15

Expected to finish

2018-10-25

Last updated by the study team

2020-01-29

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• valid driver's license
• english-speaking and literate

You may not qualify if…

• using daily medication for chronic condition
• acute narrow angle glaucoma
• previous adverse experience with study drugs
• experiences motion sickness in response to driving simulator
• BMI > 30
• women who are pregnant, lactating, or planning on becoming pregnant
• regular use of tobacco products
• current substance use disorder
• clinically significant ECG
• current ongoing psychiatric disorder

Where it is running

• Center on Drug and Alcohol Research — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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