Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

Recruiting now · Phase 3

Conditions studied: Giant Cell Tumor of Bone

In brief

The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.

Key facts

Study ID

NCT03295981

Run by

St. Louis University

People needed

120

Starts

2018-05-03

Expected to finish

2028-01-01

Last updated by the study team

2026-04-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Primary benign GCT of bone
• Lesion located in an extremity
• Lesion amenable to reconstruction (intralesional curettage) defined as having at least one intact column of bone after removal
• No previous systemic bisphosphonate or denosumab therapy

You may not qualify if…

• Recurrent GCT of bone
• Non-extremity location
• Lesion too extensive for intralesional treatment, either due to bone loss, joint invasion, or large soft tissue component
• Children and pregnancy
• Previous systemic bisphosphonate or denosumab therapy

Where it is running

• All India Institute of Medical Science — New Delhi, India (enrolling)
• Indiana University — Indianapolis, Indiana, United States (enrolling)
• University of Iowa — Iowa City, Iowa, United States (enrolling)
• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
• University of Oklahoma — Oklahoma City, Oklahoma, United States (enrolling)
• Allegheny-Singer Research Institute — Pittsburgh, Pennsylvania, United States (enrolling)
• University of California - Los Angeles — Los Angeles, California, United States (enrolling)
• Johns Hopkins University Hospital — Baltimore, Maryland, United States (enrolling)
• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
• Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States (enrolling)
• Saint Louis University — St Louis, Missouri, United States (enrolling)
• University of Kansas — Overland Park, Kansas, United States
• McGill University Health Centre — Montreal, Quebec, Canada
• University of Washington — Seattle, Washington, United States
• Wake Forest University — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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