A Study of OMP-336B11 in Subjects With Locally Advanced or Metastatic Tumors
Stopped early · Phase 1
Conditions studied: Locally Advanced Malignant Neoplasm, Metastatic Cancer
In brief
The purpose of this study is to test the safety and efficacy of OMP-336B11. OMP-336B11 is an engineered human protein that was designed to bind to the GITR receptor on T cells and activate the immune system to recognize and eliminate cancer cells.
Key facts
- Study ID
- NCT03295942
- Run by
- OncoMed Pharmaceuticals, Inc.
- People needed
- 24
- Starts
- 2017-09-12
- Expected to finish
- 2019-07-04
- Last updated by the study team
- 2020-08-11
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Locally advanced or metastatic solid tumors that have exhausted standard of care therapy
- Measurable disease per response evaluation criteria in solid tumors (RECIST) v1.1
- Age >21 years
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Adequate organ and marrow function
- For women of childbearing potential and men with partners of childbearing potential, agreement (by patient and/or partner) to use two effective forms of contraception from study entry through at least 6 months after the termination visit.
- Ability to understand and the willingness to sign a written informed consent document
You may not qualify if…
- Receiving any other investigational agents or any other anti-cancer therapy
- Active autoimmune disease or a history of severe autoimmune disease or syndrome
- History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
- Pregnancy, lactating or breastfeeding women
- History of primary CNS malignancy, or leptomeningeal disease or CNS metastases
- Significant uncontrolled intercurrent illness that will limit the patient's ability to participate in the study
- Inability to comply with study and follow up procedures
Where it is running
- South Texas Accelerated Research Therapeutics, LLC — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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