Transgender Post-reassignment Urogynecologic Measures and Perceptions

Status unconfirmed

Conditions studied: Gender Identity Disorder of Adult, Voiding Disorders, Sexual Dysfunction

In brief

The intent of this mixed methods study for transgender women after gender confirmation surgery is to characterize and subsequently create a validated screening questionnaire for postoperative urologic and pelvic floor symptoms. For individuals who seek gender-confirming treatment, about 13% undergo genital surgery for cosmetic purposes with or without gonadectomy, and this number is increasing. Patient satisfaction following surgery is high, particularly regarding sexual and cosmetic outcomes; however, unexpected negative functional outcomes such as bowel and bladder dysfunction and pelvic organ prolapse impact overall patient satisfaction. The available information suggests that 16-33% of patients experience incontinence postoperatively, with stress predominance, 32-47% experience abnormal voiding, and 24-66% experience overactive bladder symptoms. Outside of the typically assessed voiding symptoms, unique complaints of MTF postoperative patients include obstructive voiding symptoms due to urethral stenosis, persistent perimeatal erectile tissue, prostatic hypertrophy, and irritation from neovaginal tissue. Additionally, may of these patients develop symptomatic neovaginal prolapse, requiring re-suspension. We suggest that further clarification regarding MTF postoperative urologic and pelvic floor complaints can be achieved via a mixed methods approach. By using focus group interviews to create specific evaluative questions for this unique population, we can then prospectively assess patients undergoing surgery via a national multicenter sampling strategy. The goal of the study is to better understand the unique symptoms these women experience and create a validated, reliable screening questionnaire to monitor patients after surgery.

Key facts

Study ID: NCT03293771
Run by: Weill Medical College of Cornell University
People needed: 200
Starts: 2017-12-27
Expected to finish: 2019-12-31
Last updated by the study team: 2019-04-23

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

Stage 1 -- Male-to-female transgender women who are at least 4 weeks postoperative following genital surgery for gender confirmation
Stage 2 -- Male-to-female transgender women who are scheduled to undergo surgery or are within 4 weeks postoperative
Both stages -- Minimum age 18 years old
Both stages -- English fluency
Both stages -- Reliable contact information and/or permanent residence

You may not qualify if…

Preexisting pelvic pathology, including abnormal anatomy or baseline voiding dysfunction
Urinary or intestinal problems prior to surgery lasting greater than 6 weeks

Where it is running

Weill Cornell Medicine — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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