Collagen Vitamin C Dose Response Performance

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy Volunteers

In brief

Previous work has shown that gelatin supplementation could increase collagen synthesis in humans. In this study subjects consume placebo, 5 or 15 g of gelatin with a standard amount of vitamin C (48 mg) 1 hour before 6 minutes of jump rope exercise. The feeding and exercise intervention was repeated every 6 hours while the subjects were awake for three days and the amount of the amino terminal procollagen I peptide (PINP) was determined; a marker of collagen synthesis, in the blood. Consistent with the hypothesis that gelatin increases collagen synthesis in humans; the amount of PINP in the 15 g gelatin group was significantly higher than either the placebo or the 5 g groups. These data conclusively demonstrate that gelatin supplementation can increase exercise-induced collagen synthesis in humans. Hydrolyzed collagen has a similar amino acid profile, in particular with high concentrations of glycine, proline, hydroxyproline, and arginine. Thus the current study aims to precisely map out the dose response relationship of hydrolyzed collagen and vitamin C on PINP and to determine the optimal dose to achieve maximal increased in PINP levels.

Key facts

Study ID

NCT03293004

Run by

University of California, Davis

People needed

23

Starts

2017-09-13

Expected to finish

2018-05-24

Last updated by the study team

2018-08-21

Who can join

Age: 18 and older, up to 25. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Collegiate level male athletes between 18 - 25 years of age
• Currently registered/participating as an intercollegiate athlete
• < 3 musculoskeletal injuries in the past year
• No health or dietary restriction that would be affected by the supplementation protocol.

You may not qualify if…

• History of more than 3 musculoskeletal injuries within the past 12 months.
• Health, dietary restriction or diet that would be affected by the supplementation protocol.
• Then initial phases of this study will be performed in males since collagen synthesis varies significantly throughout the menstrual cycle in females. Since collagen in the main outcome measure for this study this natural variation would confound the initial phase of the work. Provided this work proves successful then we will aim to perform similar studies in females.

Where it is running

• University of California Davis — Davis, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.