Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential
Recruiting now
Conditions studied: Ischemic Stroke, Atheroscleroses, Cerebral
In brief
The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).
Key facts
- Study ID
- NCT03291652
- Run by
- Chinese University of Hong Kong
- People needed
- 140
- Starts
- 2010-02-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-02-24
Who can join
Age: 30 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Inclusion Criteria for the Symptomatic Group:
- Patient is 30 to 85 years of age, inclusive.
- Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism, a relevant intracranial atherosclerotic stenosis ≥60%, and MES detected by TCD.
- Patient who has no contra-indication for the proposed imaging tests.
- Patient understands the purpose and requirements of the study, and has provided an informed consent.
- Inclusion Criteria for the Asymptomatic Group:
- Patient is 30 to 85 years of age, inclusive.
- Patient who has a high-grade (>60%) intracranial stenosis (signal void in MR angiography) but without infarct in the corresponding vascular territory in DWI or T2-weighted sequence.
- Patient has no MES detected on TCD examination.
- Patient who has no contra-indication for the proposed imaging tests.
- Patient understands the purpose and requirements of the study, and has provided an informed consent.
You may not qualify if…
- Subject who meets one or more of the following criteria cannot be recruited in the study:
- Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease, etc.
- A tandem stenosis >50% at proximal internal carotid artery.
- Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets <100 x 109/L), coagulopathy (INR >1.5).
- A medical condition that would not allow the patient to adhere to the protocol or complete the study.
Where it is running
- Chinese University of Hong Kong — Hong Kong, Hong Kong (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.