Effect of Orally Delivered Phytochemicals on Aging and Inflammation in the Skin

Completed · Not applicable

Conditions studied: Healthy Adults

In brief

The objective is to determine, in a small number of participants, the protective effects of UV-induced skin erythema (reddening or "sunburn") following oral administration of sulforaphane, curcumin, or a combination of the two plant (diet)-based supplements. The investigators will be using the over-the-counter nutritional supplements Crucera-SGS and Meriva-SF to deliver the biologically stable sulforaphane precursor and a highly bioavailable formulation of curcumin. Volunteers will be challenged with UV irradiation at 2-times the minimum erythematous dose (M.E.D.) on discrete 2 cm diameter circles on the upper buttocks. Skin redness will be monitored daily using a chromometer. Biomarkers will then be evaluated in blood, urine, and skin biopsies.

Key facts

Study ID: NCT03289832
Run by: Johns Hopkins University
People needed: 25
Starts: 2017-09-25
Expected to finish: 2019-10-23
Last updated by the study team: 2020-07-21

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

18-70 years old, healthy
Willingness to avoid sun exposure to study site
Willingness to adhere to cruciferous vegetable-free diet

You may not qualify if…

Use of photosensitizing medications
Use of medications that cause skin flushing
Use of anticoagulants/antiplatelet therapies
Allergies to anesthetic agents
Use of systemic retinoids or steroids (excluding female contraceptives and levothyroxin)
Topical retinoids or steroids at study sites
Antibiotic use
Current students of the Principal Investigator
Procedures performed at the study sites
Smokers/tobacco users

Where it is running

Johns Hopkins — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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