Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis

Completed · Phase 4

Conditions studied: Knee Osteoarthritis

In brief

This study is intended to compare whether bone marrow aspirate concentrate or platelet rich plasma injections is more effective in treating knee osteoarthritis.

Key facts

Study ID

NCT03289416

Run by

Andrews Research & Education Foundation

People needed

90

Starts

2013-12-05

Expected to finish

2020-02-01

Last updated by the study team

2025-04-20

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female age 18-80 years
• Knee osteoarthritis
• Subjects must present with pain or swelling to target knee for at least 4 months
• Kellgren-Lawrence score between 1 and 3 upon x-ray evaluation
• Must be willing and able to provide informed consent
• Willing and able to return for scheduled follow-up visits

You may not qualify if…

• Major mechanical axis deviation of more than 50% into either compartment (varus or valgus )
• Have had a corticosteroid injection within 3 months or a hyaluronic acid injection within 6 months
• History of the following medical conditions:
• diabetes
• autoimmune disorders
• disorders requiring immunosuppression
• rheumatoid arthritis
• hemophilic arthropathy
• infectious arthritis
• Charcot's knee
• Paget's disease of the femur or tibia
• Cancer
• Ongoing infectious disease
• Significant cardiovascular, renal or hepatic disease

Where it is running

• Andrews Research & Education Foundation — Gulf Breeze, Florida, United States

Full record on ClinicalTrials.gov

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