Dysregulated CNS Inflammation After Acute Brain Injury

Completed

Conditions studied: Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage

In brief

By doing this study, the investigator hopes to learn how the levels of important proteins involved in inflammation change over time in patients with acute brain injury. The total amount of time participants will be asked to volunteer for this study is approximately two hours over a five day period.

Key facts

Study ID

NCT03287557

Run by

University of Kentucky

People needed

8

Starts

2018-01-02

Expected to finish

2019-05-24

Last updated by the study team

2019-08-29

Who can join

Age: 18 and older, up to 101. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• severe, non-penetrating TBI or aSAH
• must have a ventriculostomy (EVD) placed by the UK Neurosurgery service within 12 hours of primary traumatic episode

You may not qualify if…

• non-survivable brain injury or other organ system injury
• life expectancy is five days or less
• penetrating TBI
• status epilepticus upon arrival to the hospital
• severe ischemic heart disease or congestive heart failure, myocardial infarction, or spinal cord injury
• Takotsubo cardiomyopathy secondary to the SAH
• active cancer or have been treated for cancer within the previous 6 months

Where it is running

• University of Kentucky Deparment of Neurosurgery, UK Chandler Hospital — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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