A Study of Ketogenic Diet in Newly Diagnosed Overweight or Obese Endometrial Cancer Patients

Completed · Not applicable

Conditions studied: Endometrial Cancer

In brief

The purpose of this study is to test any good and bad effects of an experimental diet, called a ketogenic diet, in endometrial cancer. A ketogenic diet is one that is very low in carbohydrates (simple and complex sugars). The goal of this diet is for the body to go into a state of ketosis. Ketosis is when the body does not have enough sugar for energy so it burns stored fats which create acids called ketones, which can be used for energy. Researchers hope to learn whether or not a ketogenic diet is well-tolerated and safe to eat before surgery in endometrial cancer patients.

Key facts

Study ID: NCT03285152
Run by: Memorial Sloan Kettering Cancer Center
People needed: 19
Starts: 2018-02-19
Expected to finish: 2026-06-24
Last updated by the study team: 2026-06-29

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Patients must have a diagnosis endometrial carcinoma on a tissue sample obtained at MSK (biopsy). Patients with the following histologic epithelial cell types are eligible: endometrioid adenocarcinoma, serous adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, mixed epithelial carcinoma, adenocarcinoma not otherwise specified (N.O.S.), mucinous adenocarcinoma, squamous cell carcinoma, transitional cell carcinoma, carcinosarcoma.
Age ≥ 18 years
Patients must have consented to surgery with a board-certified Gyn surgeon
Patients must have no had adjuvant therapy for the management of endometrial carcinoma. This includes chemotherapy, chemotherapy and radiation therapy, and/or consolidation/maintenance therapy. Chemotherapy administered in conjunction with primary radiation as a radio-sensitizer WILL be counted as a systemic chemotherapy regimen. This also pertains to hormonal, vascular, and targeted therapy for the management of endometrial cancer.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
Patients with stage I-IVA are eligible
Adequate hematologic defined by the following laboratory results obtained within 11 days prior to first study treatment:
Absolute neutrophil count (ANC) ≥1.5 k/mcl
Platelet count ≥ 100k/mcl
Hemoglobin ≥ 9.0 g/dL
Adequate hepatic function defined by the following laboratory results obtained within 11 days prior to first study treatment:
Total bilirubin≤1.5x the upper limit of normal (ULN)
AST and ALT ≤ 3.0x ULN
Albumin ≥ 3.5 g/dL
Adequate renal function defined by the following laboratory results obtained within 11 days prior to first study treatment:
° Serum creatinine≤1.5x ULN OR creatinine clearance ≥50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation
HbA1c ≤ 7.9 %
BMI ≥ 23 kg/m2
Patients must agree to consent to the companion genomic profiling study MSK IRB# 12-245
Patients must agree to consent for their tumor samples to be used for generation of cellular research tools such as organoids
Willingness to travel to the CTSC at WCMC weekly
Patient and/or Legally Authorized Representative must have the ability to read, write, speak and understand English. Note: If patient does not have the capability to read or write in English, the patient"s preferred language should be English and the LAR will be responsible for completing all study forms on the patient's behalf.

You may not qualify if…

History of diabetes and on active diabetes treatment with pharmacotherapy (oral hypoglycemics or insulin)
History of gout.
History of myocardial infarction or unstable angina within 6 months prior to first study treatment.
Active infection requiring antibiotics (with the exception of uncomplicated urinary tract infection)
New York Heart Association Class II or greater congestive heart failure.
Patients with a QTc interval of >450 msec on screening electrocardiogram (ECG) for men or >470 msec for women.
History of malabsorption syndrome or other condition that would interfere with enteral absorption.
Inability or unwillingness to swallow
Clinically significant history of liver disease, including cirrhosis and current alcohol abuse.
Known active hepatitis infection
Known HIV infection.
Need for current chronic corticosteroid therapy (≥ 10 mg of prednisone per day or an equivalent dose of other anti-inflammatory corticosteroids)
Pregnancy, lactation, or breastfeeding
Patients of childbearing potential must have a negative pregnancy test within 11 days prior to treatment start to be eligible
Current severe, uncontrolled systemic disease (e.g., clinically significant cardiovascular, pulmonary, or metabolic disease)
Major surgical procedure or significant traumatic injury within 28 days prior to Day 1 or anticipation of the need for major surgery during the course of study treatment.
Known untreated or active central nervous system (CNS) metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control). Patients with a history of treated CNS metastases are eligible, provided that they meet all of the following criteria:
Presence of measurable disease outside the CNS
No radiographic evidence of worsening upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study
No history of intracranial hemorrhage or spinal cord hemorrhage
No ongoing requirement for dexamethasone as therapy for CNS disease (anticonvulsants at a stable dose are allowed)
Absence of leptomeningeal disease
Inability to comply with study and follow-up procedures
Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that, in the investigator's opinion, gives reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the patient at high risk from treatment complications.
History of nephrolithiasis or nephrolithiasis including that incidentally discovered during CT screening.

Where it is running

Memorial Sloan Kettering Basking Ridge (Consent and Follow up) — Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Monmouth (Consent and follow-up only) — Middletown, New Jersey, United States
Memorial Sloan Kettering Bergen (Consent and Follow up) — Montvale, New Jersey, United States
Memorial Sloan Kettering Cancer Center @ Commack (Consent and Follow up) — Commack, New York, United States
Memorial Sloan Kettering Westchester (Consent & Follow Up) — Harrison, New York, United States
New York Weill Cornell Cancer Center at Cornell University — New York, New York, United States
Memorial Sloan Kettering Cancer Center — New York, New York, United States
Memorial Sloan Kettering Nassau (Consent and Follow-up) — Rockville Centre, New York, United States

Full record on ClinicalTrials.gov

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