Cognitive Remediation Therapy (CRT) for Adults Treated for Cancer

Completed · Not applicable

Conditions studied: Cancer of the Prostate, Cancer

In brief

This study is to determine the safety, feasibility and acceptability of an 8-week cognitive remediation training (CRT) in patients treated for cancer. The secondary objective of the study is to estimate the effect size of CRT in improving neurocognitive functioning and quality of life. This is a single-arm proof of concept study. Patients treated for cancer with persistent cognitive complaints will be recruited from the outpatient clinic of the VA Comprehensive Cancer Center, West Haven, CT, Yale Medicine, and greater New Haven community.The active treatment phase will be followed by an assessment at the conclusion of treatment to evaluate changes in cognitive function and quality of life. Participants will be invited back to participate in a final follow-up assessment 2 months later.

Key facts

Study ID

NCT03285048

Run by

Yale University

People needed

12

Starts

2017-01-01

Expected to finish

2017-09-01

Last updated by the study team

2018-10-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants who:
• are at least six months from completion of adjuvant chemotherapy or chemoradiation and are in remission or;
• are receiving long-term chemotherapy (6 months or longer) with a diagnosis of Stage IV cancer and with stable medical conditions or;
• are receiving long-term (6 months or longer) hormone therapy (androgen deprivation therapy or anti-estrogen therapy). Patients in this group who received chemotherapy will be eligible if they completed chemotherapy at least 6 months prior to enrolling.
• Subjective reports of cognitive decline. 3. Report that they are interested in seeking treatment to address their cognitive concerns.
• Age 18 or older. 5. Fluency in English and a 6th grade or higher reading level.

You may not qualify if…

• Does not meet one of the three participant categories
• Unstable medical condition.
• History of, or current symptoms of, serious psychiatric disorder requiring antipsychotic medications or hospitalization.
• Current substance abuse disorder.
• History of, or current central nervous system (CNS) malignancies, CNS radiation, intrathecal chemotherapy, or CNS-involved surgery.
• Current IQ estimate less than 80.
• Unable to give written informed consent.

Where it is running

• VA Connecticut Healthcare System — West Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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