A Registry for Patients Taking Uptravi

Completed

Conditions studied: Pulmonary Arterial Hypertension

In brief

This is a US multi-center, prospective, real world, observational drug registry enrolling patients actively treated with Uptravi. Participating patients will be followed prospectively for a maximum of 18 months from the date of enrollment into the registry.

Key facts

Study ID

NCT03278002

Run by

Actelion

People needed

800

Starts

2016-11-01

Expected to finish

2021-09-21

Last updated by the study team

2025-03-30

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed patient informed consent form (ICF).
• Patients ≥ 18 years of age at time of Uptravi initiation, and
• Patients who initiate Uptravi:
• at enrollment, or
• less than or equal to 60 days prior to enrollment and have a documented titration regimen (defined as all documented dose changes including, but not limited to: starting dose and dates and highest tolerated dose and dates)

You may not qualify if…

• Patients previously exposed to Uptravi treatment during a clinical trial.
• Patients that previously discontinued Uptravi for any reason, prior to study enrollment (discontinuation defined as an interruption of therapy greater than or equal to 30 days).
• Patients enrolled in a blinded clinical trial or in a clinical trial involving an unapproved drug.

Where it is running

• Pulmonary Associates — Phoenix, Arizona, United States
• Cardioivascular Consultants, Ltd. — Phoenix, Arizona, United States
• University of Arizona-Clinical Translational and Regenerative Medicine — Tucson, Arizona, United States
• University of California San Diego — La Jolla, California, United States
• University of Southern California — Los Angeles, California, United States
• VA Greater Los Angeles Healthcare Center — Los Angeles, California, United States
• UCSF Medical Center — San Francisco, California, United States
• Santa Barbara Cottage Hospital — Santa Barbara, California, United States
• Lundquist Institute for Biomedical Innovation at Harbor-UCLA — Torrance, California, United States
• University of Colorado — Aurora, Colorado, United States
• National Jewish Health — Denver, Colorado, United States
• Banner Health Research Institute — Greeley, Colorado, United States
• Florida Lung Asthma and Sleep Specialists — Celebration, Florida, United States
• Broward Pulmonary and Sleep — Fort Lauderdale, Florida, United States
• University of Florida, HSC — Gainesville, Florida, United States
• West Pasco Pulmonary Associates — Hudson, Florida, United States
• University of Florida-Jacksonville College of Medicine — Jacksonville, Florida, United States
• Central Florida Pulmonary Group — Orlando, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Cleveland Clinic Florida — Weston, Florida, United States
• Emory University School of Medicine — Atlanta, Georgia, United States
• Wellstar Marietta Pulmonary Medicine — Marietta, Georgia, United States
• University of Chicago Hospitals — Chicago, Illinois, United States
• Indiana University Health — Indianapolis, Indiana, United States
• University of South Alabama — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

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