Maternal Autoimmune Disease Research Alliance (MADRA) Registry

Recruiting now

Conditions studied: Autoimmune Diseases, Pregnancy Related, Systemic Lupus Erythematosus, Cutaneous Lupus, Rheumatoid Arthritis, Sjogren's Syndrome, Scleroderma

In brief

This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy. Prior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outcomes. The future research will seek to better define these risk factors and to identify ways to may improve them.

Key facts

Study ID

NCT03276923

Run by

Duke University

People needed

1000

Starts

2018-01-01

Expected to finish

2027-01-01

Last updated by the study team

2026-01-08

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Desire for pregnancy within 6 months or currently pregnant
• Women with systemic autoimmune disease, including:
• Lupus (systemic lupus erythematosus or cutaneous lupus)
• Antiphospholipid Syndrome or positive antiphospholipid antibodies
• Rheumatoid Arthritis
• Scleroderma (systemic sclerosis)
• Sjogren's Syndrome
• Inflammatory Arthritis (including Psoriatic Arthritis and Ankylosing Spondylitis)
• Undifferentiated Connective Tissue Disease (UCTD)
• Vasculitis
• Myositis (Polymyositis or Dermatomyositis)
• Positive Ro/SSA or La/SSB antibodies

You may not qualify if…

• Unable to speak English
• Unable to provide informed consent
• Unable to travel to Duke University for follow-up visits

Where it is running

• Duke University — Durham, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.