Safety & Tolerability of Hypertonic Saline Administration Via Intraosseous Access

Completed · Phase 2

Conditions studied: Stroke, Intracranial Hypotension, Cerebral Edema

In brief

Hypertonic saline is used to treat elevated intracranial pressure. Intraosseous vascular access has been used to administer fluids and medications. This study combines these to administer 3% hypertonic saline via IO.

Key facts

Study ID

NCT03276494

Run by

Ohio State University

People needed

6

Starts

2017-04-21

Expected to finish

2018-04-21

Last updated by the study team

2019-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• NCCU patients in which osmotherapy with HTS is planned (standard of care
• Does not already have a CVC or PICC.

You may not qualify if…

• <18 years old
• Known pregnancy
• Long bone fracture in the targeted site
• Proximity to prosthetic joint
• Excessive tissue/absence of anatomical landmarks
• History of osteopetrosis
• Previous significant orthopedic procedure at site
• Prosthetic limb or joint
• IO catheter use in the past 48 hours of the target bone
• Infection at the area of insertion
• Hypersensitivity to lidocaine

Where it is running

• The Ohio State University — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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